There have been 152 Serie A matches between Fiorentina and Lazio. The record stands at 59 wins for Lazio, 43 draws and 50 wins for Fiorentina. The Viola have scored a total of 190 goals, while Lazio have scored 211. Silvio Piola, with his 11 goals, is the top scorer of the fixture. He is followed by Gabriel Batistuta and Kurt Hamrin, both at 10. Bruno Giordano and Ciro Immobile both scored eight goals and are followed by Pierluigi Casiraghi and Giuseppe Signori with six each. Completing the list are Miguel Montuori and Hernan Crespo with five.

The latest match between the two teams at the Olimpico ended with Fiorentina winning 1-2 in January 2025, with goals by Yacine Adli and Lucas Beltran. Fiorentina have won all the past three Serie A games against Lazio, with all of them ending 2-1. This will also be the first competitive encounter between Paolo Vanoli and Maurizio Sarri.

Two Lazio players used to play for Fiorentina: Matias Vecino played in Florence from 2015 to 2017, making 61 appearances and scoring five goals in Serie A; so far at Lazio he has tallied 93 appearances and 10 goals in the top flight. Danilo Cataldi rose through the ranks at Lazio, where he made 204 appearances and scored eight goals in Serie A; last season he joined Fiorentina, where he made 25 appearances and scored three goals.

Another former player of the fixture is Gaetano Castrovilli, who scored 12 goals for Fiorentina and made 111 appearances in Serie A; he then joined Lazio in 2024, where he played in nine matches. Christian Vieri also played for both teams; at Lazio he scored 12 goals in 22 games in the 1998/99 season, while at Fiorentina he scored six goals in 26 appearances in the 2007/08 season. Mauro Zarate mesmerized the Olimpico with his 25 goals in 104 Serie A games, and then went on to score five in 22 appearances in Florence. Valon Behrami tallied 65 appearances and scored four goals for Lazio and then made 48 appearances for Fiorentina between 2011 and 2012. Lorenzo De Silvestri rose through the ranks at Lazio and played for the club from 2005 to 2009, making a total of 47 appearances; he then joined Fiorentina, where he totaled 74 appearances and two goals between 2009 and 2012. Another former player of the fixture is Milan Badelj, who played for Fiorentina from 2014 to 2018 and made 164 appearances; he then joined Lazio, where he made 26 appearances, and then returned to Florence the following year. Sinisa Mihajlovic played for Lazio for six seasons, making 126 appearances and scoring 20 goals; he then became Fiorentina coach starting from the 2010/11 season.

Lazio are facing several major absences: Tijjani Noslin and Adam Marusic will be unavailable, as they were sent off during their last Serie A match, while Patric is currently injured, and Boulaye Dia is on international duty at the Africa Cup of Nations.

The match will also be an important opportunity for some players to set personal records. At Fiorentina, Pietro Comuzzo may make his 50^th Serie A appearance, while forward Roberto Piccoli could reach his 150^th appearance in the top flight. At Lazio, all eyes are on Gustav Isaksen, who may make his 100^th appearance for his team.